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    已发表论文

    基质金属蛋白酶-1 的启动子多态性与胃癌风险之间的关联

     

    Authors Peng QS, Xu Y
    Received 17 February 2015
    Accepted for publication 14 July 2015
    Published 10 September 2015 Volume 2015:8 Pages 2519—2526
    DOI http://dx.doi.org/10.2147/OTT.S83004
    Checked for plagiarism Yes
    Review by Single-blind
    Peer reviewer comments 3
    Editor who approved publication:  Professor Daniele Santini

    Abstract: Growing evidences show that matrix metalloproteinase-1 (MMP1 ) plays important roles in tumorigenesis and cancer metastasis. The interactions between MMP1 -1607 1G>2G polymorphism and risk of gastric cancer (GC) have been reported, but results remained ambiguous. To determine the association between MMP1 -1607 1G>2G polymorphism and risk of GC, we conducted a meta-analysis and identified the outcome data from all the research papers estimating the association between MMP1 -1607 1G>2G polymorphism and GC risk, which was based on comprehensive searches using databases such as PubMed, Elsevier Science Direct, Excerpta Medica Database (EMBASE), and Chinese National Knowledge Infrastructure (CNKI). The fixed-effects model was used in this meta-analysis. Data were extracted, and pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. In this meta-analysis, six studies involving 1,377 cases and 1,543 controls were included. We identified the significant association between MMP1 -1607 1G>2G polymorphism and GC risk for allele model (OR =1.05; 95% CI, 1.01-1.08), for dominant model (OR =1.11; 95% CI, 1.08-1.15), and for recessive model (OR =1.06; 95% CI, 0.98-1.14). In summary, our analysis demonstrated that MMP1 -1607 1G>2G polymorphism was significantly associated with an increased risk of GC.
    Keywords: MMP1 , gene polymorphisms, gastric cancer


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