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已发表论文
在中国大肠癌患者中，Ku70 与 ATM 下调与不良预后相关
Authors Lu YF, Gao JY, Lu YM
Published Date October 2014 Volume 2014:7 Pages 1955—1961
DOI http://dx.doi.org/10.2147/OTT.S67814
Received 15 May 2014, Accepted 6 August 2014, Published 24 October 2014
Approved for publication by Dr Faris Farassati
Background: Double-strand DNA breaks (DSBs) are a key factor in carcinogenesis. The necessary repair of DSBs is pivotal in maintaining normal cell division. To address the relationship between altered expression of DSB repair of proteins Ku70 and ataxia-telangiectasia mutated (ATM) in colorectal cancer (CRC), we examined the expression levels and patterns of Ku70 and ATM in CRC samples.
Methods: Expression and coexpression of Ku70 and ATM were investigated by using real-time quantitative polymerase chain reaction assays and confirmed further with fluorescent immunohistochemistry in CRC and pericancerous samples from 112 Chinese patients.
Results: Downexpression patterns for both Ku70 and ATM were found in the CRC samples and were significantly associated with advanced tumor node metastasis stage and decreased 5-year overall survival rate.
Conclusion: Downregulated Ku70 and ATM were associated with poor disease-free survival. Loss of Ku70 and ATM expression might act as a biomarker to predict poor prognosis in patients with CRC.
Keywords: DNA double-strand breaks, ataxia-telangiectasia mutated, Ku70, colorectal cancer
Methods: Expression and coexpression of Ku70 and ATM were investigated by using real-time quantitative polymerase chain reaction assays and confirmed further with fluorescent immunohistochemistry in CRC and pericancerous samples from 112 Chinese patients.
Results: Downexpression patterns for both Ku70 and ATM were found in the CRC samples and were significantly associated with advanced tumor node metastasis stage and decreased 5-year overall survival rate.
Conclusion: Downregulated Ku70 and ATM were associated with poor disease-free survival. Loss of Ku70 and ATM expression might act as a biomarker to predict poor prognosis in patients with CRC.
Keywords: DNA double-strand breaks, ataxia-telangiectasia mutated, Ku70, colorectal cancer
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