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已发表论文

顺利获得家族淀粉样多发性神经病变细胞自噬模式，姜黄素可以减少 TTR 与 Tyr114Cys 突变的单体

 

Authors Li H, Zhang Y, Cao L, Xiong R, Zhang B, Wu L, Zhao Z, Chen SD

Published Date October 2014 Volume 2014:8 Pages 2121—2128

DOI http://dx.doi.org/10.2147/DDDT.S70866

Received 9 July 2014, Accepted 16 August 2014, Published 31 October 2014

Approved for publication by Professor Shu-Feng Zhou

Abstract: Transthyretin (TTR) familial amyloid polyneuropathy (FAP) is an autosomal ­dominant inherited neurodegenerative disorder caused by various mutations in the transthyretin gene. We aimed to identify the mechanisms underlying TTR FAP with Tyr114Cys (Y114C) mutation. Our study showed that TTR Y114C mutation led to an increase in monomeric TTR and impaired autophagy. Treatment with curcumin resulted in a significant decrease of monomeric TTR by recovering autophagy. Our research suggests that impairment of autophagy might be involved in the pathogenesis of TTR FAP with Y114C mutation, and curcumin might be a potential therapeutic approach for TTR FAP.
Keywords: curcumin, familial amyloid polyneuropathy, transthyretin, autophagy



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