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    已发表论文

    培美曲塞在非小细胞肺癌和转移性肺结节治疗中的关键评价

     

    Authors Li X, Wei S, Chen J

    Published Date June 2014 Volume 2014:7 Pages 937—945

    DOI http://dx.doi.org/10.2147/OTT.S45148

    Received 29 November 2013, Accepted 17 February 2014, Published 6 June 2014

    Abstract: Pemetrexed, a new multitarget antifolate antineoplastic agent, has significantly improved the overall survival in nonsquamous non-small-cell lung cancer patients. Presently, pemetrexed is recommended for first line treatment in combination with platinum derivatives, for second line treatment as a single agent and, more recently, as maintenance treatment after first line chemotherapy. In this article we critically appraise the status of pemetrexed including pharmacodynamics, pharmacokinetics, toxicity, and the cost effectiveness of pemetrexed, as well as the predictive biomarkers for pemetrexed based chemotherapy.

    Keywords: chemotherapy, non-small-cell lung cancer, pemetrexed


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