Dan-Dan Wang,1,2 Shi-Guang Ren,1,2 Rui Hu,1,2 Hui-Lan Zhai,1 Fen Xie,1 Lu Jiang,1 Wen-Lei Huang,3 Xue-Qin Li3 

1Department of Gastroenterology, the 2nd Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330006, People’s Republic of China; 2School of Nursing, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330006, People’s Republic of China; 3Nursing Department, the 2nd Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330006, People’s Republic of China

Correspondence: Xue-Qin Li, Nursing Department, the 2 nd Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 1 of Minde Road, Donghu District, Nanchang, 330006, People’s Republic of China, Tel +86 13870892330, Email xueqinlidrlxq@outlook.com

Abstract: Inflammatory bowel disease (IBD) encompasses chronic inflammatory conditions of the digestive tract, including Crohn’s disease and ulcerative colitis. Fatigue is one of the common and important extraintestinal symptoms in IBD patients, which significantly affects the patient’s ability to work, daily life, social activities, emotional state, and cognitive function. Although the impact of fatigue on patients’ quality of life cannot be ignored, medical professionals still have limited knowledge of its concepts, assessment tools, influencing factors, and non-pharmacological interventions, which may lead to neglect and inadequate management of the symptoms. The purpose of this article is to review the definition and epidemiological characteristics of IBD-related fatigue and to discuss the application of four commonly used fatigue assessment tools in patients with IBD. In addition, we will analyze the multiple factors that affect fatigue in IBD patients from three levels: physiological, psychological, and sociodemographic. Finally, we will assess the effectiveness of different non-pharmacological interventions in alleviating fatigue in people with IBD and make corresponding clinical recommendations.

Keywords: inflammatory bowel disease, fatigue, assessment tools, influencing factors, non-pharmacological interventions, review