Ebpay生命医药出版社

      • Ebpay生命

      100763

      论文已发表

      提 交 论 文


      注册即可获取Ebpay生命的最新动态

      注 册



      IF 收录期刊



      • 3.3 Breast Cancer (Dove Med Press)
      • 3.4 Clin Epidemiol
      • 2.5 Cancer Manag Res
      • 2.9 Infect Drug Resist
      • 3.5 Clin Interv Aging
      • 4.7 Drug Des Dev Ther
      • 2.7 Int J Chronic Obstr
      • 6.6 Int J Nanomed
      • 2.5 Int J Women's Health
      • 2.5 Neuropsych Dis Treat
      • 2.7 OncoTargets Ther
      • 2.0 Patient Prefer Adher
      • 2.3 Ther Clin Risk Manag
      • 2.5 J Pain Res
      • 2.8 Diabet Metab Synd Ob
      • 2.8 Psychol Res Behav Ma
      • 3.0 Nat Sci Sleep
      • 1.8 Pharmgenomics Pers Med
      • 2.7 Risk Manag Healthc Policy
      • 4.2 J Inflamm Res
      • 2.1 Int J Gen Med
      • 4.2 J Hepatocell Carcinoma
      • 3.7 J Asthma Allergy
      • 1.9 Clin Cosmet Investig Dermatol
      • 2.7 J Multidiscip Healthc



      更多详情 >>





      已发表论文

      司美格鲁肽对肥胖所致肾病及肥胖所致肾透明细胞癌的保护作用

       

      Authors Wang S, Zhang M, Yang X, Chen S

      Received 29 September 2024

      Accepted for publication 11 March 2025

      Published 19 March 2025 Volume 2025:18 Pages 805—818

      DOI http://doi.org/10.2147/DMSO.S498447

      Checked for plagiarism Yes

      Review by Single anonymous peer review

      Peer reviewer comments 2

      Editor who approved publication: Professor Liang Wang

      Shuqi Wang,1,2 Mengmeng Zhang,1,2 Xiaoman Yang,1,2 Shuchun Chen1– 3 

      1Department of Internal Medicine, Hebei Medical University, Shijiazhuang, People’s Republic of China; 2Department of Endocrinology, Hebei General Hospital, Shijiazhuang, People’s Republic of China; 3Key Laboratory of Metabolic Diseases in Hebei Province, Shijiazhuang, People’s Republic of China

      Correspondence: Shuchun Chen, Department of Endocrinology, Hebei General Hospital, Shijiazhuang, People’s Republic of China, Tel/Fax +86 31185988406, Email chenshuc2014@163.com

      Purpose: Proteomics was used to study the effect of semaglutide on the expression of renal protein in obese mice, and looking for proteins that could improve the prognosis of Kidney Renal Clear Cell Carcinoma (KIRC).
      Materials and Methods: Thirty-six mice were randomly divided into normal-fat diet group (NFD), high-fat diet group (HFD), high-fat diet plus semaglutide intervention group (HS). Collected mice serum, urine, kidney tissue samples, and detected urinary protein/creatinine, blood glucose, blood lipid, inflammation, oxidative stress and other related indicators. Different staining methods were used to analyze the pathological changes of mice’s kidneys. Liquid chromatography-tandem mass spectrometry mass spectrometry (LC-MS/MS) analysis was used to analyze the total protein in the kidneys of mice. Finally, bioinformatics technology was used to analyze significantly different expressed proteins (DEPs).
      Results: The mechanism of semaglutide protecting the kidneys were related to oxidative phosphorylation, PPAR signaling pathway, thiamine, butyric acid and tryptophan metabolism pathways. Moreover, semaglutide could significantly increase the expression of Man1a1 and Ntn4 in the kidneys of mice, while the high-expression of Man1a1 and Ntn4 in KIRC population had a better overall survival rate.
      Conclusion: Semaglutide could regulate the development of KIRC by up-adjusting the expression of Man1a1 and Ntn4.

      Keywords: obesity, semaglutide, kidney renal clear cell carcinoma, proteomics

      Download Article[PDF]