Meiqin Chen,1 Xiguo Chen,2 Shun Wang,1 Dan Lei,1 Chunxian Peng1 

1Department of Infectious Diseases, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou, People’s Hospital, Quzhou, People’s Republic of China; 2Department of Electromechanical Engineering, Quzhou College of Technology, Quzhou, People’s Republic of China

Correspondence: Chunxian Peng, Email springpeng1999@163.com

Background: Hepatic angiosarcoma is an extremely rare, uncontrollable tumor with strong invasion, high mortality rate, and extremely poor prognosis. There is first report on hepatic angiosarcoma accompanied by eosinophilia.
Case Presentation: A woman with a chief complaint of poor appetite for about 3 months presented to a local hospital with a liver mass. Laboratory examination revealed a significant increase in eosinophils count was 9.58% in the serum. Abdominal MRI revealed multiple focal high-density lesions in the liver and spleen, and cranial MRI revealed multiple high-density shadows in the skull. Laparoscopic biopsy revealed a hepatic angiosarcoma and targeted treatment with Anlotinib was performed. Two months later, the patient died of splenic rupture and bleeding.
Conclusion: Hepatic angiosarcoma often has no specific clinical manifestations, and we found that this case can lead to an increase in eosinophils, which is worth the attention of clinical physicians.

Keywords: hepatic angiosarcoma, eosinophilia, prognosis, diagnosis, case report