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中性粒细胞胞外陷阱在动脉粥样硬化中的作用：从分子机制到临床研究
Authors Yuan Y, Sun C , Liu X, Hu L, Wang Z, Li X, Zhang J, Li D, Zhang X, Wu M, Liu L
Received 27 November 2024
Accepted for publication 13 March 2025
Published 26 March 2025 Volume 2025:18 Pages 4421—4433
DOI http://doi.org/10.2147/JIR.S507330
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Prof. Dr. Kattepura Krishnappa Dharmappa
摘要：动脉粥样硬化是一种以中大动脉脂质沉积及继发炎症反应为特征的慢性炎症性疾病。中性粒细胞胞外陷阱（neutrophil extracellular traps, NETs）是中性粒细胞在病理状态下活化后释放的由DNA、组蛋白和颗粒酶等成分构成的网状结构。除了清除病原体外，NETs对动脉粥样硬化的发生开展也具有关键调控作用。本文综述了动脉粥样硬化相关危险因素刺激NETs形成、而NETs又进一步有助于疾病进展的双向作用关系，重点阐述了NETs顺利获得影响血管内皮、血小板、炎性微环境及脂质代谢等环节参与动脉粥样硬化斑块形成与进展的多阶段机制。并且本研究为深入理解动脉粥样硬化中的血管炎性微环境的形成与调控机制给予了新的研究视角。最后，探讨了针对NETs的潜在靶向治疗策略，以有助于其向临床转化。
