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顺利获得高分辨率磁共振成像（MRI）和弥散张量成像（DTI）评估椎间盘突出所致单侧 S1 神经损伤的临床症状
Authors Zhang C , Hao W, Guo X, Zhang Y, Fu H, Zhang J
Received 21 November 2024
Accepted for publication 9 April 2025
Published 18 April 2025 Volume 2025:18 Pages 2105—2114
DOI http://doi.org/10.2147/JPR.S507867
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Michael A Ueberall
ChaoYang Zhang,1,* Wei Hao,1,* Xiaobo Guo,2 Yuna Zhang,1 Hao Fu,1 Jiashan Zhang1
1Department of Radiology, Jincheng General Hospital, Jincheng, Shanxi, People’s Republic of China; 2Department of Orthopaedics, Jincheng General Hospital, Jincheng, Shanxi, People’s Republic of China
*These authors contributed equally to this work
Correspondence: ChaoYang Zhang, Email Zhangchaoyang8717@163.com
Background: The status of the herniated disc or nucleus pulposus and the extent of injury and clinical symptoms of the compressed S1 nerve fiber bundle were evaluated by high-resolution Magnetic resonance imaging (MRI) and Diffusion tensor imaging (DTI) techniques.
Methods: Forty-two clinically proven patients with unilateral S1 nerve root compression were selected as the case group (n=42), and 20 healthy volunteers were selected as the control group (n=20). The general data, MRI features and DTI parameters were compared between groups. The effective indicators of S1 neurologic fiber bundle damage were screened by univariate logistic regression analysis and receiver operating characteristic (ROC) curve, and multi-factor logistic regression models were constructed to analyze the diagnostic efficiency of each model.
Results: There were no significant differences in age, gender, height, weight, fractional anisotropy (FA) value and apparent diffusion coefficient (ADC) value on both sides of S1 nerve root between groups (P > 0.05). The FA value and ADC value of the nerve root on the affected side of the patient were significantly different from those on the healthy side and those on the corresponding side of the control group (all P < 0.05), and all of them were effective indicators of the damage of S1 nerve. The sensitivity, specificity and area under the curve of the damaged nerve fiber bundle were detected by multi-factor logistic regression models constructed with FA+rFA and FA+rFA+rADC of the affected nerve root, respectively 95.20%, 72.00%, 0.939, and 97.60%, 80.00%, 0.944.
Conclusion: High-resolution MRI and DTI can quantitatively evaluate the degree of nerve fiber bundle injury and clinical symptoms caused by lumbar disc herniation.
Keywords: lumbar disc herniation, high-resolution MRI, DTI, fractional anisotropy, apparent diffusion coefficient
