Xueqin Gu,1,* Hongmei Shen,2,* Jiafeng Jiang,1,* Ping Gu,2,* Peilong Liu,2 Zhenguo Zhao,3 Jinfang Ge1 

1Department of Dermatology, The Second People’s Hospital of Nantong, Nantong, Jiangsu Province, People’s Republic of China; 2Department of Clinical Laboratory, The Second People’s Hospital of Nantong, Nantong, Jiangsu Province, People’s Republic of China; 3Department of Emergency Medicine, The Second People’s Hospital of Nantong, Nantong, Jiangsu Province, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Zhenguo Zhao, Department of Emergency Medicine, Nantong Second People’s Hospital, No. 298 Xinhua Road, Chongchuan District, Nantong City, Jiangsu Province, 226000, People’s Republic of China, Tel +86-15250957146, Email 453558071@qq.com Jinfang Ge, Department of Dermatology, Nantong Second People’s Hospital, No. 298 Xinhua Road, Chongchuan District, Nantong City, Jiangsu Province, 226000, People’s Republic of China, Tel +86-15996679525, Email gjf1066@sohu.com

Objective: The monocyte-to-high-density lipoprotein ratio (MHR) has emerged as a novel inflammatory biomarker associated with cardiovascular diseases (CVDs). This retrospective study aimed to investigate the relationship between MHR and the Framingham risk score (FRS) and assess the prognostic significance of this relationship for mid- to high-risk CVD in individuals with psoriasis vulgaris (PsV).
Methods: A total of 128 PsV patients and 120 healthy controls were included. The neutrophil-to-high-density lipoprotein ratio (NHR), MHR, and neutrophil-to-lymphocyte ratio (NLR) were assessed and compared between the two groups. Correlations between MHR and FRS were evaluated.
Results: PsV patients with intermediate to high cardiovascular risk exhibited significantly higher NHR, MHR, and NLR compared to controls (p = 0.018, p = 0.002, p < 0.001, respectively). Furthermore, FRS was positively correlated with MHR, NHR, and NLR in the PsV patients (r=0.27, p =  0.002; r=0.21, p =  0.017 and r=0.33, p < 0.001, respectively). Logistic regression analysis identified age, sex, and the MHR as influencing factors for the FRS (p < 0.05). Receiver operating characteristic (ROC) curve analysis revealed that the highest Youden’s index (0.316) was obtained at an MHR of 0.24, with sensitivity, specificity, and area under the ROC curve of 0.729, 0.587, and 0.662 (95% CI of 0.565, 0.758), respectively.
Conclusion: MHR was significantly associated with FRS, which may serve as a valuable predictor of medium to high risk of CVDs in patients with PsV.

Keywords: psoriasis vulgaris, cardiovascular diseases, monocyte, high-density lipoprotein cholesterol, Framingham risk score