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已发表论文

射频导管消融术后心房颤动复发与炎症负担指数相关

 

Authors Peng S, Li F, Jin M, Zhang Y, Li H, Yin J

Received 21 January 2025

Accepted for publication 12 May 2025

Published 15 May 2025 Volume 2025:21 Pages 681—689

DOI http://doi.org/10.2147/TCRM.S518620

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Professor De Yun Wang

Siliang Peng, Feng Li, Mengchao Jin, You Zhang, Hui Li, Jiayu Yin

Department of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215004, People’s Republic of China

Correspondence: Jiayu Yin, Department of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215004, People’s Republic of China, Email 782240393@qq.com

Background: Recurrence rates of atrial fibrillation (AF) remain high after radiofrequency catheter ablation (RFCA), and inflammation plays an important role in the process. Inflammatory burden index (IBI) as a new inflammatory marker has been found to be associated with worse prognosis in cardiovascular disease. But there are no studies on its role in predicting AF recurrence. The aim of this study was to assess the value of IBI in predicting recurrence of AF after RFCA.
Methods: This was a single-center retrospective observational study. Consecutive enrolment of PersAF who underwent first-time radiofrequency ablation between January 2021 and June 2024. Inflammatory Burden Index (IBI) was calculated as C-reactive protein (CRP) × neutrophil/lymphocyte (NLR).
Results: A total of 142 (27.2%) patients experienced recurrence after RFCA. Multivariate analysis showed that PersAF (OR = 1.599; 95% CI: 1.028 ~ 2.486, p = 0.018), CHA2DS2-VASc score≥ 2 (OR = 1.769; 95% CI: 1.142 ~ 2.741, p = 0.011), LAD (OR = 1.098; 95% CI: 1.054 ~ 1.145, p < 0.001) and IBI (OR = 1.028; 95% CI: 1.007 ~ 1.050, p = 0.009), were independent predictors of recurrence. ROC analysis shows superiority of IBI (AUC=0.695, 95% CI: 0.647 ~ 0.743, p < 0.001) over CRP and NLR in predicting AF recurrence. When IBI was integrated into the traditional model (including PersAF, LAD and CHA2DS2-VASc Score), the discrimination and reclassification accuracy for the recurrence were significantly improved.
Conclusion: Inflammatory load index associated with the recurrence of AF after RFCA. Integration of IBI can improve the model about the recurrence of AF after RFCA.

Keywords: atrial fibrillation, radiofrequency catheter ablation, recurrence, inflammation, inflammatory burden index

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