102494
论文已发表
提 交 论 文
注册即可获取Ebpay生命的最新动态
注 册
IF 收录期刊
- 3.3 Breast Cancer (Dove Med Press)
- 3.4 Clin Epidemiol
- 2.5 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.5 Clin Interv Aging
- 4.7 Drug Des Dev Ther
- 2.7 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.5 Int J Women's Health
- 2.5 Neuropsych Dis Treat
- 2.7 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.3 Ther Clin Risk Manag
- 2.5 J Pain Res
- 2.8 Diabet Metab Synd Ob
- 2.8 Psychol Res Behav Ma
- 3.0 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.7 Risk Manag Healthc Policy
- 4.2 J Inflamm Res
- 2.1 Int J Gen Med
- 4.2 J Hepatocell Carcinoma
- 3.7 J Asthma Allergy
- 1.9 Clin Cosmet Investig Dermatol
- 2.7 J Multidiscip Healthc
急性脑出血患者血清转录因子 EB 水平与不良神经预后的关系及脑卒中相关性肺炎的中介作用：一项来自两家中心的前瞻性队列研究的证据
Authors Wang K, Zhan G, Jiang Q, Jiang C, Zheng G, Tang Z
Received 5 February 2025
Accepted for publication 8 May 2025
Published 19 May 2025 Volume 2025:18 Pages 2539—2552
DOI http://doi.org/10.2147/IJGM.S519757
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Redoy Ranjan
Kang Wang,1 Guoyong Zhan,1 Qingsong Jiang,1 Cai Jiang,1 Guofu Zheng,1 Zhuxiao Tang2
1Department of Neurosurgery, QuZhou KeCheng People’s Hospital, Quzhou, Zhejiang Province, People’s Republic of China; 2Brain Center, Zhejiang Hospital, Hangzhou, Zhejiang Province, People’s Republic of China
Correspondence: Guoyong Zhan, Department of Neurosurgery, QuZhou KeCheng People’s Hospital, Quzhou, Zhejiang Province, People’s Republic of China, Email zgy686618@163.com
Background: Transcription factor EB (TFEB) is an endogenous protective protein. Serum TFEB levels were measured after acute intracerebral hemorrhage (ICH), in addition to determining their connection to the severity and neurological outcomes of patients.
Methods: Serum TFEB levels were measured in a prospective cohort study of 186 ICH patients and 100 controls. Severity was estimated using the National Institutes of Health Stroke Scale (NIHSS) and hematoma volume. Poor neurological status mirrored by the post-ICH six-month modified Rankin Scale (mRS), along with stroke-associated pneumonia (SAP), was considered as the two outcome variables.
Results: Patients showed a marked decline in serum TFEB levels compared with controls. Serum TFEB levels were significantly inversely correlated with both NIHSS scores and hematoma volume; had a linear relationship with likelihoods of both SAP and poor prognosis (mRS scores 3– 6), were independent of ordinal mRS scores, SAP, and poor prognosis; and were efficiently predictive of SAP and poor prognosis with analogous areas under the receiver operating characteristic curve as NIHSS scores and hematoma volume. The association between serum TFEB levels and poor prognosis is partly mediated by SAP.
Conclusion: Reduced serum TFEB levels post-ICH of evident relevance to bleeding intensity are powerfully linked to poor neurological prognosis, wherein there is a partial mediative effect by SAP, thereby reinforcing TFEB as a serological prognostic indicator of good prospect in ICH.
Keywords: transcription factor EB, intracerebral hemorrhage, outcome, severity, stroke-associated pneumonia, biomarkers
