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急性缺血性脑卒中患者血清 D-二聚体、中性粒细胞与淋巴细胞比值（NLR）及 C 反应蛋白/白蛋白（CRP/ALB）的相关性
Authors Luo GB , Yan DL, Luo CL, Jiang SS, Wang ZJ, Li XS
Received 6 January 2025
Accepted for publication 4 May 2025
Published 27 May 2025 Volume 2025:18 Pages 2749—2756
DOI http://doi.org/10.2147/IJGM.S516037
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Woon-Man Kung
Guo-Biao Luo, Di-Li Yan, Chao-Liu Luo, Sha-Sha Jiang, Zong-Jun Wang, Xiao-Song Li
Department of Neurology second Ward, The People’s Hospital of the Qiandongnan Miao and Dong Autonomous Prefecture, Kaili, 556000, People’s Republic of China
Correspondence: Guo-Biao Luo, Department of Neurology second ward, The People’s Hospital of the Qiandongnan Miao and Dong Autonomous Prefecture, No. 31 of Shaoshan South Road, Kaili, 556000, Guizhou Province, People’s Republic of China, Tel +86 15208551980, Email guobiaoluo_lgb@126.com
Objective: This study examines the association between serum D-dimer (D-D), neutrophil-to-lymphocyte ratio (NLR), C-reactive protein to albumin ratio (CRP/ALB), and the prognosis of intravenous thrombolysis in patients with acute ischemic stroke (AIS).
Methods: Ninety AIS patients admitted from June 2021 to October 2023 were included and divided into poor prognosis (29 cases) and good prognosis groups (61 cases) based on 90-day follow-up modified Rankin Scale (mRS) scores. Binary logistic regression identified prognostic factors, while ROC analysis evaluated the predictive efficacy of D-D, NLR, and CRP/ALB. Correlations among these markers were also analyzed.
Results: Binary logistic regression showed that age, D-D, ALB, CRP/ALB, neutrophil count, lymphocyte count, and NLR were significant prognostic risk factors (P < 0.05). ROC analysis yielded AUC values of 0.683 for D-D, 0.769 for NLR, and 0.728 for CRP/ALB, with combined AUC reaching 0.803. Sensitivity and specificity were 96.6%/39.3% for D-D, 100.0%/68.9% for NLR, and 100.0%/45.9% for CRP/ALB. Spearman correlation analysis revealed positive correlations among D-D, NLR, and CRP/ALB (r = 0.367, 0.482, 0.462, p < 0.05).
Conclusion: Age, D-D, ALB, CRP/ALB, neutrophil count, lymphocyte count, and NLR are significant prognostic factors for intravenous thrombolysis in AIS patients. D-D, NLR, and CRP/ALB are effective indicators for predicting prognosis, with combined prediction showing greater efficacy.
Keywords: acute ischemic stroke, D-dimer, intravenous thrombolysis, lymphocyte count, neutrophil count
