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已发表论文

联合全身免疫炎症指数 - 预后营养指数评分在评估重症社区取得性肺炎患者预后中的应用

 

Authors Chen X, Hao L, Zhou Y, Zhang H, Wang H, Yu W

Received 21 February 2025

Accepted for publication 24 May 2025

Published 31 May 2025 Volume 2025:18 Pages 7105—7114

DOI http://doi.org/10.2147/JIR.S521440

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Xiaoyu Liu

XiaoFei Chen, LingLi Hao, Yujing Zhou, Huihui Zhang, Huaying Wang, Wanjun Yu

Department of Respiratory and Critical Care Medicine, The Affiliated People’s Hospital of Ningbo University, Ningbo, Zhejiang, People’s Republic of China

Correspondence: XiaoFei Chen, Department of Respiratory and Critical Care Medicine, The Affiliated People’s Hospital of Ningbo University (Ningbo Yinzhou People’s Hospital), Ningbo, Zhejiang, People’s Republic of China, Email rmchenxiaofei@nbu.edu.cn

Background: While both the systemic immune-inflammation index (SII) and prognostic nutritional index (PNI) have demonstrated prognostic value in various diseases, the clinical utility of their combined score (SII-PNI) for predicting outcomes in patients with severe community-acquired pneumonia (SCAP) remains incompletely understood. The aim of this study is to explore the predictive value of SII-PNI score in patients with SCAP.
Methods: We conducted a retrospective analysis of the clinical data of 138 patients diagnosed with SCAP. The SII, PNI, and the SNII-PNI score were calculated. Receiver operating characteristic (ROC) curve analysis was performed to determine the optimal threshold of SII-PNI. Multivariable logistic regression models were used to assess the association between the SII-PNI score and 28-day mortality.
Results: The cutoff values for predicting 28-day mortality were > 4689.82 for SII and < 32.18 for PNI, respectively, with sensitivities of 59.1% and 60.3% and specificities of 85.3% and 68.2%. Multivariate analysis reveals that a SII-PNI score of 2 (OR, 14.11; 95% CI, 3.18– 62.66; p = 0.001) was independently associated with a high risk of 28-day mortality.
Conclusion: Our results indicate that a higher SII-PNI score at admission was linked to poor prognosis in SCAP patients. The combined SII-PNI score can effectively help clinicians assess disease progression and optimize risk assessment and clinical management for SCAP patients.

Keywords: severe community-acquired pneumonia, systemic immune-inflammation index, SII, prognostic nutritional index, PNI, SII-PNI score, prognosis

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