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已发表论文
CXCR4 在治疗非小细胞肺癌中的临床病理意义
Authors Zhou X, He L, Hou G, Jiang B, Wang Y, Zhao L
Published Date March 2015 Volume 2015:9 Pages 1349—1358
DOI http://dx.doi.org/10.2147/DDDT.S71060
Received 12 July 2014, Accepted 25 September 2014, Published 5 March 2015
Background: Emerging evidence indicates that C-X-C chemokine receptor type 4 (CXCR4)
is a candidate oncogene in several types of human tumors including non-small
cell lung cancer (NSCLC). However, the correlation between CXCR4 expression and
clinicopathological characteristics of NSCLC remains unclear. Here, we
conducted a meta-analysis to quantitatively evaluate the association of CXCR4
expression with the incidence of NSCLC and clinicopathological characteristics.
Methods: A detailed literature search was made from Medline and Web of Science for related research publications written in English and Chinese. The methodological quality of the studies was also evaluated. Analyses of pooled data were performed. Odds ratio (OR) and hazard ratio (HR) were calculated and summarized.
Results: The final analysis of 1,446 NSCLC patients from 13 eligible studies was performed. We observed that CXCR4 expression was significantly higher in NSCLC than in normal lung tissue from the pooled OR from five studies including 380 NSCLC and 118 normal lung tissue (OR=12.86, 95% confidence interval =3.63–45.59, P <0.0001). CXCR4 expression was not associated with smoking status and type of pathology. However, CXCR4 expression was significantly associated with clinical stages, metastatic status, and overall survival in NSCLC patients.
Conclusion: The results of this meta-analysis suggest that CXCR4 expression is associated with an increased risk and worse survival in NSCLC patients. The aberrant CXCR4 expression plays an important role in the carcinogenesis and metastasis of NSCLC.
Keywords: chemokine, clinicopathological factor, hazard ratio, meta-analysis, odds ratio
Methods: A detailed literature search was made from Medline and Web of Science for related research publications written in English and Chinese. The methodological quality of the studies was also evaluated. Analyses of pooled data were performed. Odds ratio (OR) and hazard ratio (HR) were calculated and summarized.
Results: The final analysis of 1,446 NSCLC patients from 13 eligible studies was performed. We observed that CXCR4 expression was significantly higher in NSCLC than in normal lung tissue from the pooled OR from five studies including 380 NSCLC and 118 normal lung tissue (OR=12.86, 95% confidence interval =3.63–45.59, P <0.0001). CXCR4 expression was not associated with smoking status and type of pathology. However, CXCR4 expression was significantly associated with clinical stages, metastatic status, and overall survival in NSCLC patients.
Conclusion: The results of this meta-analysis suggest that CXCR4 expression is associated with an increased risk and worse survival in NSCLC patients. The aberrant CXCR4 expression plays an important role in the carcinogenesis and metastasis of NSCLC.
Keywords: chemokine, clinicopathological factor, hazard ratio, meta-analysis, odds ratio
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