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已发表论文
中性粒细胞与淋巴细胞的比例对食管癌患者预后的意义：一项综合分析
Authors Yang X, Huang Y, Feng JF, Liu JS
Published Date April 2015 Volume 2015:8 Pages 789—794
DOI http://dx.doi.org/10.2147/OTT.S77099
Received 6 November 2014, Accepted 10 February 2015, Published 10 April 2015
Background: The neutrophil-to-lymphocyte ratio (NLR) is a useful predictive factor
in several cancers. However, the prognostic value of NLR in patients with
esophageal cancer (EC) is still controversial. Therefore, it was necessary for
us to perform a meta-analysis to evaluate the prognostic value of NLR in
patients with EC.
Methods: A systematic literature search was performed by using Web of Science, PubMed Central, and Medline to evaluate the prognostic value of NLR in patients with EC. The deadline of our primary search was July 10, 2014. This meta-analysis was conducted in accordance with PRISMA guidelines. Pooled hazard ratio (HR) with 95% confidence interval (CI) was used to assess the association of NLR and overall survival (OS) and disease-free survival (DFS).
Results: Six studies involving 1,633 patients were included in our meta-analysis. Our pooled results demonstrated that high NLR was associated with poor OS (HR: 1.54, 95% CI: 1.32–1.80, I 2=25.3%, P =0.254) and DFS (HR: 1.74, 95% CI: 1.25–2.43, I 2=63.9%, P =0.096). Subgroup analysis between NLR and OS was performed in a further investigation. When the patients were segregated according to country, sample size, and pathological type, high NLR was also significantly correlated with OS.
Conclusion: High NLR is associated with poor prognosis in patients with EC. NLR may be a significant predictive biomarker in patients with EC.
Keywords: esophageal cancer, neutrophil-to-lymphocyte ratio, prognosis, meta-analysis, overall survival, disease-free survival
Methods: A systematic literature search was performed by using Web of Science, PubMed Central, and Medline to evaluate the prognostic value of NLR in patients with EC. The deadline of our primary search was July 10, 2014. This meta-analysis was conducted in accordance with PRISMA guidelines. Pooled hazard ratio (HR) with 95% confidence interval (CI) was used to assess the association of NLR and overall survival (OS) and disease-free survival (DFS).
Results: Six studies involving 1,633 patients were included in our meta-analysis. Our pooled results demonstrated that high NLR was associated with poor OS (HR: 1.54, 95% CI: 1.32–1.80, I 2=25.3%, P =0.254) and DFS (HR: 1.74, 95% CI: 1.25–2.43, I 2=63.9%, P =0.096). Subgroup analysis between NLR and OS was performed in a further investigation. When the patients were segregated according to country, sample size, and pathological type, high NLR was also significantly correlated with OS.
Conclusion: High NLR is associated with poor prognosis in patients with EC. NLR may be a significant predictive biomarker in patients with EC.
Keywords: esophageal cancer, neutrophil-to-lymphocyte ratio, prognosis, meta-analysis, overall survival, disease-free survival
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