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已发表论文

后天性因子 V 抑制剂在头孢他啶 (ceftazidime) 治疗后的开展：病例报告和文献回顾

 

Authors Cui QY, Shen HS, Wu TQ, Chen HF, Yu ZQ, Wang ZY

Published Date April 2015 Volume 2015:9 Pages 2395—2398

DOI http://dx.doi.org/10.2147/DDDT.S68682

Received 31 May 2014, Accepted 28 August 2014, Published 24 April 2015

Abstract: We report the case of a 59-year-old Chinese man who showed an asymptomatic coagulation factor V deficiency pattern after second intravenous treatment with ceftazidime. Normal pooled plasma failed to correct the abnormalities in a mixing test, and the presence of factor V inhibitor was confirmed by the Bethesda method. The coagulopathy was not corrected by transfusion of fresh frozen plasma and prothrombin complex concentrate, but rather by treatment with prednisone and withdrawal of dubious drugs. The findings reported here should prompt clinicians to watch for drug-induced coagulation factor deficiency.
Keywords: acquired factor V deficiency, coagulopathy, prednisone






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