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已发表论文
特异性囊肿病液体蛋白-15 (GCDFP-15)，雄激素受体 (AR) 和人表皮生长因子受体-2 (Her-2) 作为泪腺原发性导管腺癌的生物标记：一个中国案例与文献回顾
Authors Zhu MM, Cui HG, Teng XD
Published Date May 2015 Volume 2015:8 Pages 1017—1024
DOI http://dx.doi.org/10.2147/OTT.S82168
Received 4 February 2015, Accepted 26 March 2015, Published 11 May 2015
Purpose: Primary ductal adenocarcinoma (PDA) of the lacrimal gland is a rare
malignant epithelial tumor, and its clinicopathological characteristics are
still unclear. This study aimed to report a novel case of PDA of the lacrimal
gland in the People’s Republic of China, as well as to determine its
histopathological and immunohistochemical characteristics to support early
diagnosis and direct further therapy.
Patient and methods: Clinical data (including ocular examination, computed tomography, magnetic resonance imaging, positron emission tomography, mammography, and serum tumor marker examination) and treatment of a 49-year-old woman with a left lacrimal gland mass, which was diagnosed as PDA of the lacrimal gland, were reported. Histopathological and immunohistochemical studies were performed. Eleven papers regarding this uncommon neoplasm were reviewed.
Results: Histopathologically, most of the tumor cells featured abundant granular eosinophilic cytoplasm, while few of them had a frothy appearance. The mass showed breast ductal carcinoma-like structural features, which most commonly demonstrated central necrosis, while less of these features showed cord-like infiltration. Immunohistochemically, the tumor cells were positive for GCDFP-15, CK 18 (++), AR (90%), Her-2 (+++), P53 (100%), and Ki-67 (with a proliferation index approximately 60%), while they were negative for ER, PR, P63, calponin, and CD 117.
Conclusion: This was the first Chinese case of PDA of the lacrimal gland that had been reported. We suggested that GCDFP-15, AR, and Her-2 should be tested as biomarkers for ductal adenocarcinoma of lacrimal gland to confirm diagnosis, guide therapy, and further predict prognosis.
Keywords: GCDFP-15, androgen receptors, Her-2, ductal adenocarcinoma, lacrimal gland, orbital tumor
Patient and methods: Clinical data (including ocular examination, computed tomography, magnetic resonance imaging, positron emission tomography, mammography, and serum tumor marker examination) and treatment of a 49-year-old woman with a left lacrimal gland mass, which was diagnosed as PDA of the lacrimal gland, were reported. Histopathological and immunohistochemical studies were performed. Eleven papers regarding this uncommon neoplasm were reviewed.
Results: Histopathologically, most of the tumor cells featured abundant granular eosinophilic cytoplasm, while few of them had a frothy appearance. The mass showed breast ductal carcinoma-like structural features, which most commonly demonstrated central necrosis, while less of these features showed cord-like infiltration. Immunohistochemically, the tumor cells were positive for GCDFP-15, CK 18 (++), AR (90%), Her-2 (+++), P53 (100%), and Ki-67 (with a proliferation index approximately 60%), while they were negative for ER, PR, P63, calponin, and CD 117.
Conclusion: This was the first Chinese case of PDA of the lacrimal gland that had been reported. We suggested that GCDFP-15, AR, and Her-2 should be tested as biomarkers for ductal adenocarcinoma of lacrimal gland to confirm diagnosis, guide therapy, and further predict prognosis.
Keywords: GCDFP-15, androgen receptors, Her-2, ductal adenocarcinoma, lacrimal gland, orbital tumor
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