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已发表论文
鞘氨醇激酶 1 作为抗癌治疗靶点
Authors Gao Y, Gao F, Chen K, Tian ML, Zhao DL
Published Date June 2015 Volume 2015:9 Pages 3239—3245
DOI http://dx.doi.org/10.2147/DDDT.S83288
Received 21 February 2015, Accepted 29 April 2015, Published 23 June 2015
Approved for publication by Professor Shu-Feng Zhou
Abstract: The development of chemotherapeutic resistance is a major challenge in oncology. Elevated sphingosine kinase 1 (SK1) levels is predictive of a poor prognosis, and SK1 overexpression may confer resistance to chemotherapeutics. The SK/sphingosine-1-phosphate (S1P)/sphingosine-1-phosphate receptor (S1PR) signaling pathway has been implicated in the progression of various cancers and in chemotherapeutic drug resistance. Therefore, SK1 may represent an important target for cancer therapy. Targeting the SK/S1P/S1PR signaling pathway may be an effective anticancer therapeutic strategy, particularly in the context of overcoming drug resistance. This review summarizes our current understanding of the role of SK/S1P/S1PR signaling in cancer and development of SK1 inhibitors.
Keywords: sphingosine kinase 1, S1P, S1PR, inhibitors, cancer, therapy
Keywords: sphingosine kinase 1, S1P, S1PR, inhibitors, cancer, therapy
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