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已发表论文

中国人群前体 miR-218 rs11134527 多态性与患癌风险的定量评价

 

Authors Zhao HY, Wang R

Published Date July 2015 Volume 2015:8 Pages 1859—1862
DOI http://dx.doi.org/10.2147/OTT.S88480
Received 13 May 2015, Accepted 8 June 2015, Published 24 July 2015

Peer reviewers approved by Dr Liying Geng

Approved for publication by Professor Daniele Santini

 

Background: Accumulated studies have evaluated the association of pre-miR-218 rs11134527 polymorphism with cancer risk in Chinese population. However, the results remain controversial.

Methods: To derive a more precise and more comprehensive estimation of the relationship, six studies focused on Chinese population were included for the pooled analysis for pre-miR-218 rs11134527 polymorphism using odds ratios (ORs) with 95% confidence intervals (CIs).
Results: Pre-miR-218 rs11134527 polymorphism was associated with cancer risk (G versus A, OR =0.93, 95% CI: 0.88–0.98; GG versus AG + AA, OR =0.88, 95% CI: 0.79–0.97; GG versus AA, OR =0.85, 95% CI: 0.76–0.96). In the stratified analysis by cancer type, the pre-miR-218 rs11134527 polymorphism was only associated with the risk of cervical cancer (G versus A, OR =0.90, 95% CI: 0.83–0.98; GG versus AG + AA, OR =0.80, 95% CI: 0.68–0.94; GG versus AA, OR =0.79, 95% CI: 0.66–0.94).
Conclusion: These findings suggest that the pre-miR-218 rs11134527 genetic polymorphism may decrease the susceptibility to cervical cancer, which needs to be verified or linked with functional studies.
Keywords: single-nucleotide, polymorphisms, meta-analysis, polymorphism, cancer, risk


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