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    已发表论文

    小鼠静脉内注射后，聚乙二醇涂层对纳米石墨烯氧化物的生物分布和毒性的影响

     

    Authors Li B, Zhang XY, Yang JZ, Zhang YJ, Li WX, Fan CH, Huang Q

    Published Date October 2014 Volume 2014:9(1) Pages 4697—4707

    DOI http://dx.doi.org/10.2147/IJN.S66591

    Received 21 April 2014, Accepted 4 July 2014, Published 8 October 2014


    Abstract: In this study, we assessed the in vivo behavior and toxicology of nanoscale graphene oxide (NGO) in mice after intravenous injection. The influence of a polyethylene glycol (PEG) coating on the distribution and toxicity of the NGO was also investigated. The results show that NGO is mainly retained in the liver, lung, and spleen. Retention in the lung is partially due to NGO aggregation. The PEG coating reduces the retention of NGO in the liver, lung, and spleen and promotes the clearance of NGO from these organs, but NGO and NGO-PEG are still present after 3 months. The PEG coating effectively reduces the early weight loss caused by NGO and alleviates NGO-induced acute tissue injuries, which can include damage to the liver, lung, and kidney, and chronic hepatic and lung fibrosis.
    Keywords: graphene oxide, biodistribution, toxicity, polyethylene glycol






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